Table 3.
Type 2 Inflammatory Markers by Categories of Exacerbation Frequency
| Number of Systemic Corticosteroid Bursts |
P Value | |||
|---|---|---|---|---|
| None | Few (1–2) | Prone (≥3) | ||
| Blood EOS, absolute cell count/μl | ||||
| Children (n = 187) | 363 (182, 581) | 319 (175, 522) | 415 (196, 514) | 0.911 |
| Adults (n = 521) | 201 (121, 315) | 207 (130, 372) | 230 (116, 442) | 0.461 |
| Sputum EOS, % | ||||
| Children (n = 43) | 1.5 (0.1, 10.2) | 0.9 (0.4, 3) | 1.2 (0.3, 2.5) | 0.889 |
| Adults (n = 403),* KW | 0.5 (0, 2) | 0.9 (0, 3.5) | 0.9 (0.2, 5.2) | 0.028 |
| FeNO, ppb | ||||
| Children (n = 183) | 33 (12, 63) | 22 (12, 41) | 20 (12, 44) | 0.141 |
| Adults (n = 518) | 22 (14, 35) | 23 (13, 39) | 25 (13, 42) | 0.606 |
| Blood IgE, IU/mL (excludes subjects on biologics) | ||||
| Children (n = 170) | 418 (201, 834) | 467 (142, 1,164) | 334 (169, 952) | 0.982 |
| Adults (n = 480),* KW | 161 (56, 363) | 163 (40, 386) | 93 (27, 291) | 0.007 |
| Number of positive specific IgEs (of 15 tests) | ||||
| Children | 7 (3, 11) | 7 (3, 12) | 6 (3, 9) | 0.566 |
| Adults,* CS | 4 (2, 8) | 3 (1, 7) | 2 (0, 5) | <0.001 |
Definition of abbreviations: CS = chi-square test; EOS = eosinophils; FeNO = exhaled nitric oxide; KW = Kruskal-Wallis test.
Data are expressed as median (interquartile range).
*
Significance with P less than 0.05, using the chi-square or Kruskal-Wallis test as appropriate.