Figure 1.

Estimated FEV₁ changes by Global Initiative for Chronic Obstructive Lung Disease (GOLD) group and severe exacerbations status. Estimates were obtained from linear mixed model fits (see Statistical Analyses section) for the completer and late subjects. The plot demonstrates that those with at least one severe exacerbation (dashed lines) had faster declines in FEV₁, on average, compared with those that did not (solid lines), for each GOLD group. PRISm = preserved ratio impaired spirometry.