Table 2.

Exacerbation Distributions and Annualized Rates for the Analytic Cohort Based on Longitudinal Follow-up Surveys, by GOLD Stage

	PRISm	GOLD 0	GOLD 1	GOLD 2	GOLD 3	GOLD 4
n	282	1,111	230	544	339	125
All exacerbations
≥1 event during follow-up, %	30.5	21.5	27.4	46.5	70.2	69.6
Percentage with average of 1 or more per year	12.8	4.1	7.0	12.5	28.6	35.2
Percentage with average of 2 or more per year	3.9	1.2	1.3	4.4	10.0	12.0
Mean rate, per year	0.30	0.13	0.18	0.36	0.72	0.89
Severe exacerbations
≥1 event during follow-up, %	13.5	8.1	10.0	24.1	42.2	47.2
Percentage with average of 1 or more per year	4.6	0.9	0.4	2.8	5.6	11.2
Percentage with average of 2 or more per year	1.1	0.4	0.0	0.4	0.9	1.6
Mean rate, per year	0.10	0.04	0.04	0.11	0.20	0.31

Definition of abbreviations: GOLD = Global Initiative for Chronic Obstructive Lung Disease; PRISm = preserved ratio impaired spirometry.

Longitudinal follow-up surveys were available on 1,937 of 2,000 completers and 694 of 861 late subjects in the analytic cohort, combined above.