Table 2. BDNF levels of different point times and antidepressant treatment.
| Study | Drug group | Dose | Sample | Outcome | BL | 1 week | 2 week | 4 week | 6 week | 8 week | 12 week |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mikoteit | Duloxetine (SNRI) | 65.8±16.1mg/day | Serum | BDNF | 5.01±3.64 | 8.66±5.93 | 11.03±8.0 | 7.3±5.6 | |||
| HDRS | 22.2±4.9 | 16.8±7.5 | 13.8±7.5 | 9.0±6.6 | |||||||
| Ghosh | Fluoxetine (SSRI) | 20mg/day | Plasma | BDNF | 775.32±30.38 | N/A | 850.3±24.92 | ||||
| HDRS | 19±4.09 | 12.2±4.58 | 9.24±3.98 | ||||||||
| Venlafaxine (SNRI) | 50mg/day | Plasma | BDNF | 760.5±28.53 | N/A | 845.8±32.82 | |||||
| HDRS | 18±3.75 | 13.5±3.86 | 10±3.75 | ||||||||
| Yoshimura | Paroxetin (SSRI) | 30.5±12.4 mg/day | Serum | BDNF | 8.6±7.2 | 9.2±6.1 | 11.2±8.4 | ||||
| Sertraline (SSRI) | 76.7±24.0mg/day | HDRS | 21.0±4.3 | 13.8±4.9 | 10.0±5.6 | ||||||
| Fluvoxamin (SSRI) | 100±26.3 mg/day | ||||||||||
| Martocchia | Escitalopram (SSRI) | 10mg/day | Serum | BDNF | 11.5±0.6 | 16.0±2.7 | |||||
| GDS | 9.6±3.4 | 6.4±3.6 | |||||||||
| Brunoni | Sertraline (SSRI) | 50mg/day | plasma | BDNF | 1331±786 | 1620±672 | |||||
| HDRS | 22.0±4.0 | 14.0±8.0 | |||||||||
| Munno | Paroxetin (SSRI) | 20-50mg/day | Serum | BDNF | 14.87±2.9 | 14.69±1.6 | |||||
| HDRS | 19.20±1.83 | 12.44±2.40 | |||||||||
| Plasma | BDNF | 231.45±90.08 | 312.95±109.42 | ||||||||
| HDRS | 19.20±1.83 | 12.44±2.40 | |||||||||
| Ladea | Escitalopram(SSRI) | 10mg/day | Serum | BDNF | 35.6±12.7 | 34.7±11.8 | 35.7±13.2 | ||||
| MADRS | 29.6±2.3 | ||||||||||
| Deuschle | Venlafaxine (SNRI) | 203±47mg/day | Serum | BDNF | 7.82±3.75 | 7.18±5.64 | |||||
| HDRS | 23.0±4.5 | 7.4±5.3 | |||||||||
| Mirtazapine | 46±9mg/day | BDNF | 7.64±6.23 | 8.50±5.37 | |||||||
| HDRS | 22.7±4.2 | 8.9±6.0 | |||||||||
| Dreimüller | SSNRI, SNRI, TCA, Mirtazapine, Tranylcypromine | N/A | Plasma | BDNF | 298±196 | 334±157 | |||||
| HDRS | 19 | 12 | |||||||||
| Wolkowitz | Escitalopram (SSRI) | 10-20mg/day | Serum | BDNF | 15.28 ± 3.55 | 17.46 ± 3.96 | |||||
| HDRS | 31.2 ± 7.9 | 14.5 ± 11.2 | |||||||||
| Sertraline (SSRI) | 50-200mg/day | BDNF | 14.43 ± 7.12 | 20.77 ± 10.15 | |||||||
| HDRS | 19.2 ± 4.0 | 9.7 ± 4.9 | |||||||||
| Rojas | Venlafaxine (SNRI) | 75mg/day | Serum | BDNF | 12.2±9.95 | 8.85±2.44 | |||||
| HDRS | 22.8±3.65 | 11.43±1.48 | |||||||||
| Matrisciano | Sertraline (SSRI) | 96.4±50.8 mg/day | Serum | BDNF | 29.4±12.6 | 50.6±14.2 | |||||
| HDRS | 19±5.3 | N/A | |||||||||
| Escitalopram (SSRI) | 16.4±3.8 mg/day | BDNF | 44.4±16.4 | 38.6±14.4 | |||||||
| HDRS | 14.3±5.9 | N/A | |||||||||
| Venlafaxine (SNRI) | 150±61 mg/day | BDNF | 32.3±14.0 | 29.1±16.3 | |||||||
| HDRS | 19.4±4.5 | N/A | |||||||||
| Piccinni | Citalopram, Sertraline, Paroxetine, Amitriptyline, Imipramine, Trimipramine, Desipramine | N/A | Serum | BDNF | 19.3±8.8 | 22.09±8.37 | 24.46±9.92 | ||||
| HDRS | 22.8±5.3 | ||||||||||
| Plasma | BDNF | 290.0±190.0 | 444.8±20.95 | 456.3±19.85 | |||||||
| HDRS | 22.8±5.3 | ||||||||||
| Huang | Mirtazapine. Fluoxetine, Paroxetine, Venlafaxine | N/A | Serum | BDNF | 10.7±7.3 | 12.0±8.9 | |||||
| HDRS | 35.1±4.9 | 12.1±10.8 | |||||||||
| Hellweg | Amitriptyline (TCA) | 150mg/day | Serum | BDNF | 13.001±3.744 | 15.18±5.98 | |||||
| HDRS | 23.8±5.1 | 11.0±8.1 | |||||||||
| Paroxetine (SSRI) | 40mg/day | BDNF | 13.250±5.112 | 12.02±4.85 | |||||||
| HDRS | 22.6±3.9 | 11.7±8.4 | |||||||||
| Yoshimura | Paroxetine (SSRI) | 31±13mg/day | Serum | BDNF | 9.4±7.9 | 10.4±8.2 | 17.9±7.6 | ||||
| HDRS | 24±7 | ||||||||||
| Milnacipran (SNRI) | 83±31mg/day | BDNF | 9.8±9.7 | 10.3±7.5 | 15.8±8.1 | ||||||
| HDRS | 23±6 | ||||||||||
| Aydemir | Escitalopram (SSRI) | 10 mg/day | Serum | BDNF | 27.68±13.74 | 38.57±15.30 | |||||
| HDRS | 39.75±7.40 | 9.31±6.05 | |||||||||
| Gonul | Fluoxetine, Venlafaxine | N/A | Serum | BDNF | 20.8±6.7 | 33.3±9.89 | |||||
| HDRS | 27.28±3.53 | 8.85±3.15 | |||||||||
| Aydemir | Venlafaxine (SNRI) | 75 mg/day | Serum | BDNF | 17.9±9.1 | 34.6±7.1 | |||||
| HDRS | 23.2±4.6 | 8.2±3.9 | |||||||||
| Shimizu | Amoxapine, Milnacipran, Paroxetine | N/A | Serum | BDNF | 13.32±11.97 | 28.79±6.23 | |||||
| HDRS | 33.5±10.5 | 2.8±1.0 | |||||||||
BDNF concentration: Serum, ng/ml; Plasma, pg/ml. SSRI, Selective Serotonin Reuptake Inhibitor. SNRI, selective noradrenalin reuptake inhibitors. TCA, tricyclic antipsychotics.