Table 1.
The most frequent chromosomal translocations and genetic abnormalities in sarcomas
| Histology | Incidence (%) | Chromosomal/genetic abnormalities | Genes involved |
|---|---|---|---|
| Myxoid liposarcoma24,25 | 10 | t(12;16)(q13;p11) | TLS-CHOP |
| t(12;22)(q13;q12) | EWS-CHOP | ||
| Desmoplastic small round cell tumor50 | 1 | t(11;22)(p13;q12) | EWS-WT1 |
| Alveolar soft part sarcoma51 | 1 | t(X;17)(p11.2;q25) | TFE3-ASPL |
| Ewing’s sarcoma/peripheral primitive neuroectodermal tumor52 | 1 | t(11;22)(q24;q12) | EWS-FLI1 |
| t(21;22)(q22;q12) | EWS-ERG | ||
| t(7;22)(p22;q12) | EWS-ETV1 | ||
| t(17;22)(q12;q12) | EWS-FEV | ||
| t(2;22)(q33;q12) | EWS-E1AF | ||
| t(16;21)(p11;q22) | FUS-ERG | ||
| Dermatofibrosarcoma protuberans53 | 1 | t(17;22)(q22;q13) | COL1A1-PDGFB |
| Extraskeletal myxoid chondrosarcoma54 | 1 | t(9;22)(q22;q12) | EWS-CHN |
| t(9;15)(q22;q21) | TFC12-CHN | ||
| t(9;17)(q22;q11) | TAF2N-CHN | ||
| Clear cell sarcoma55 | <1 | t(12;22)(q13;q12) | EWSR1/CREB1 |
| EWSR1/ATF1 | |||
| Inflammatory myofibroblastic tumor56 | <1 | t(q2;p23) | EML4-ALK |
| RANBP2-ALK | |||
| TFG-ROS1 | |||
| Solitary fibrous tumor57 | 1 | t(9;22)(q31;p13) | NAB2-STAT6 |
| Synovial sarcoma58 | 6–10 | t(X;18)(p11;q11) | SYT-SSX |
| Pleomorphic sarcoma/undifferentiated sarcoma26 | 15–25 | Genomic instability/complex karyotype | – |