Table S2.

Univariate and multivariate survival analyses involving posttreatment plasma IL-6

Variables	Category	Progression-free survival analyses
		Univariate analysis			Multivariate analysis
		HR	95% CI	P-value	HR	95% CI	P-value
Gender	Female/male	0.25	0.09–0.69	0.008	0.23	0.06–0.82	0.024
Age	<57/≥57 years	0.39	0.17–0.90	0.028	0.30	0.11–0.81	0.017
Smoking history	No/yes	0.35	0.14–0.91	0.031	1.69	0.45–6.45	0.439
EGFR status	Exon 19 del/others	0.31	0.12–0.79	0.014	0.28	0.10–0.76	0.013
IL-6 level*	Lower/higher	0.57	0.25–1.33	0.200	0.47	0.16–1.33	0.153

Note:

^*Patients were dichotomized based on the median value (1.7 pg/mL) of posttreatment plasma IL-6.

Abbreviations: CI, confidence interval; EGFR, epidermal growth factor receptor; HR, hazard ratio; IL, interleukin.