Figure 6.

Aldh1a1/Gpx1 knockout (KO) mice show significantly increased 4-hydroxynonenal (4-HNE) in striatum and midbrain compared to age-matched wild-type (WT) mice. (A) 6-month-old mice; (B) 18-month-old mice. Data in each group are expressed as the mean ± SEM of the number of animals in parentheses. Data were analyzed using a general linear model. The Tukey–Kramer method was used to adjust for multiple comparisons. *p < 0.05, WT vs KO at the indicated time-point.

GAPDH = glyceraldehyde-3-phosphate dehydrogenase.