Figure 3.

Quantitative Sensory Testing (QST) before and after treatment. The z-transformed pattern of 11 QST subtests (shown without dynamic mechanical allodynia (DMA) and paradoxical heat sensation (PHS), which were normal). QST reveals thermal hypoesthesia of cold stimuli (CDT) in the directly affected area (middle finger), most likely related to the loss of small fiber function (Aδ fibres). The ability to detect minimal mechanical stimuli (MDT) is reduced within (long finger), as well as outside (thenar of the same hand) the affected area, as is the ability to detect vibration (VDT) in the hand area. These mechanical deficits reflect most likely a loss of function of large diameter fibers (Aβ fibres). With the exception of VDT, treatment with BTX-A normalised the QST pattern. The red circles in the figure indicate values measured outside the two Standard Deviation (SD).