Table 1. Gene Ontology (GO) enrichments for variants with ASD GWAS OR >1 and p < 0.1 and located in genomic regions with HB score for incomplete selection in top-5%.

Parent GO are in underlined italic. Hierarchical relationships are represented by arrow symbols (→).

GO biological process	Fold Enrichment	Bonferroni P-value	P-value
synapse organization (GO:0050808)	4.09	6.76E-03	8.29E-07
→ → cellular process (GO:0009987)	1.15	1.97E-05	2.41E-09
→ single-organism cellular process (GO:0044763)	1.2	1.22E-03	1.50E-07
→ → single-organism process (GO:0044699)	1.17	9.77E-04	1.20E-07
axon guidance (GO:0007411)	3.66	1.48E-03	1.81E-07
→ axonogenesis (GO:0007409)	2.8	1.43E-02	1.75E-06
→ → axon development (GO:0061564)	2.66	2.48E-02	3.05E-06
→ → → neuron projection development (GO:0031175)	2.45	1.90E-03	2.33E-07
→ → → → cell projection organization (GO:0030030)	2.09	1.33E-03	1.63E-07
→ → → → neuron development (GO:0048666)	2.21	4.53E-03	5.55E-07
→ → → → → cell development (GO:0048468)	2.1	1.43E-07	1.76E-11
→ → → → → → cell differentiation (GO:0030154)	1.67	1.28E-07	1.57E-11
→ → → → → → → cellular developmental process (GO:0048869)	1.64	2.44E-07	2.99E-11
→ → → → → → single-organism developmental process (GO:0044767)	1.46	3.93E-06	4.81E-10
→ → → → → → → developmental process (GO:0032502)	1.44	1.46E-05	1.79E-09
→ → → → → → anatomical structure development (GO:0048856)	1.43	3.56E-05	4.37E-09
→ → → → → neuron differentiation (GO:0030182)	2.35	5.48E-06	6.73E-10
→ → → → → → generation of neurons (GO:0048699)	2.09	1.36E-06	1.66E-10
→ → → → → → → neurogenesis (GO:0022008)	2.01	5.27E-06	6.46E-10
→ → → → → → → → nervous system development (GO:0007399)	1.89	6.17E-08	7.57E-12
→ → → → → → → → → system development (GO:0048731)	1.58	3.01E-07	3.69E-11
→ → → → → → → → → → multicellular organism development (GO:0007275)	1.51	8.76E-07	1.07E-10
→ → → → → → → → → → → single-multicellular organism process (GO:0044707)	1.42	2.41E-05	2.95E-09
→ → → → → → → → → → → → multicellular organismal process (GO:0032501)	1.28	2.53E-02	3.11E-06
→ → neuron projection morphogenesis (GO:0048812)	2.67	4.66E-03	5.71E-07
→ → → cell projection morphogenesis (GO:0048858)	2.54	5.77E-05	7.08E-09
→ → → → cell morphogenesis (GO:0000902)	2.54	1.76E-07	2.16E-11
→ → → → → cellular component morphogenesis (GO:0032989)	2.42	3.84E-07	4.71E-11
→ → → → → → anatomical structure morphogenesis (GO:0009653)	1.82	3.54E-06	4.35E-10
→ → → cell part morphogenesis (GO:0032990)	2.52	5.57E-05	6.83E-09
→ → cell morphogenesis involved in neuron differentiation (GO:0048667)	2.72	7.04E-03	8.63E-07
→ → → cell morphogenesis involved in differentiation (GO:0000904)	2.92	1.81E-06	2.22E-10
→ neuron projection guidance (GO:0097485)	3.62	1.74E-03	2.13E-07
→ → movement of cell or subcellular component (GO:0006928)	1.94	2.76E-04	3.39E-08
→ → → locomotion (GO:0040011)	2.08	1.63E-04	2.00E-08
regulation of binding (GO:0051098)	3.04	7.85E-03	9.63E-07
heart development (GO:0007507)	2.71	3.03E-04	3.72E-08
→ animal organ development (GO:0048513)	1.59	2.60E-04	3.19E-08
→ cardiovascular system development (GO:0072358)	2.15	2.70E-03	3.31E-07
→ → circulatory system development (GO:0072359)	2.15	2.70E-03	3.31E-07
pattern specification process (GO:0007389)	2.61	7.79E-03	9.56E-07
sensory organ development (GO:0007423)	2.38	2.13E-02	2.61E-06
organ morphogenesis (GO:0009887)	2.09	3.74E-03	4.58E-07
cell migration (GO:0016477)	2.06	2.50E-02	3.07E-06
→ localization (GO:0051179)	1.39	1.60E-03	1.96E-07
anatomical structure formation involved in morphogenesis (GO:0048646)	2.05	1.55E-03	1.90E-07
epithelium development (GO:0060429)	1.97	2.76E-02	3.39E-06
regulation of multicellular organismal development (GO:2000026)	1.68	1.86E-02	2.29E-06
→ regulation of multicellular organismal process (GO:0051239)	1.61	4.56E-04	5.60E-08
→ regulation of developmental process (GO:0050793)	1.61	1.02E-02	1.25E-06
regulation of localization (GO:0032879)	1.54	1.88E-02	2.31E-06
positive regulation of metabolic process (GO:0009893)	1.51	5.44E-03	6.67E-07
→ positive regulation of biological process (GO:0048518)	1.36	3.58E-03	4.39E-07