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. Author manuscript; available in PMC: 2017 Feb 27.
Published in final edited form as: J Am Chem Soc. 2016 Dec 2;138(49):15861–15864. doi: 10.1021/jacs.6b10898

Figure 3.

Figure 3

MR phantom images at 4.7 T, RT, of water with 0.5 mM Mn2+-JED (A and C) or Gd-bis-5HT-DTPA (B and D) before (−) and after (+) incubation with H2O2/ peroxidase (45 U/mL). Images (A and C) acquired using a T1-weighted FLASH sequence, or (B and D) with a 325 ms inversion pre-pulse to generate large positive contrast in the oxidized sample; see SI for image acquisition details. Note the high contrast between the samples containing Mn2+- vs. Mn3+-JED, but low contrast for the Gd-based system. (E) Percentage r1 change after peroxidase mediated oxidation of the Mn- and Gd- based agents. A detailed description of the scanning parameters is in the SI.