TABLE 2.
Correlation between clinical CDI severities and genotypes of C. difficile isolates
| Molecular characterization | CDIa severity scoreb (%) |
Analysis results |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Comparison among 5 CDI severity scores |
Trend χ2 |
|||||||||
| 1 (n = 35) | 2 (n = 193) | 3 (n = 103) | 4 (n = 58) | 5 (n = 22) | Mean ± SD | χ2 | P value | χ2 | P value | |
| Toxin gene pattern | ||||||||||
| A+B+ (n = 282) | 0 | 152 (53.9) | 79 (28.0) | 44 (15.6) | 7 (2.5) | 2.67 ± 0.05 | 113.8 | <0.001 | 9.28 | 0.002 |
| A−B+ (n = 94) | 0 | 41 (43.6) | 24 (25.5) | 14 (14.9) | 15 (16.0) | 3.03 ± 0.12 | ||||
| A−B− (n = 35) | 35 (100) | 0 | 0 | 0 | 0 | 1.00 | ||||
| MLST type | ||||||||||
| ST2 (n = 46) | 0 | 29 (63.0) | 10 (21.7) | 7 (15.2) | 0 | 2.52 ± 0.11 | 19.4 | 0.001 | 3.46 | 0.063 |
| ST3 (n = 67) | 0 | 36 (53.7) | 21 (31.3) | 9 (13.4) | 1 (1.5) | 2.63 ± 0.10 | 1.85 | 0.174 | ||
| ST37 (n = 68) | 0 | 30 (44.1) | 16 (23.5) | 11 (16.2) | 11 (16.2) | 3.04 ± 0.14 | 8.04 | 0.005 | ||
| ST54 (n = 53) | 0 | 24 (45.3) | 18 (34.0) | 11 (20.8) | 0 | 2.75 ± 0.11 | 0.001 | 0.978 | ||
| Others (n = 177) | 35 (19.7) | 74 (41.8) | 38 (21.5) | 20 (11.3) | 10 (5.7) | 2.41 ± 0.08 | 0.004 | 0.947 | ||
| PCR ribotype | ||||||||||
| RT001 (n = 59) | 0 | 33 (55.9) | 18 (30.5) | 7 (11.9) | 1 (1.7) | 2.59 ± 0.10 | 21.6 | <0.001 | 2.58 | 0.108 |
| RT012 (n = 55) | 0 | 25 (45.5) | 18 (32.7) | 11 (20.0) | 1 (1.8) | 2.78 ± 0.11 | 0.11 | 0.741 | ||
| RT017 (n = 68) | 0 | 30 (44.1) | 16 (23.5) | 11 (16.2) | 11 (16.2) | 3.04 ± 0.14 | 8.70 | 0.003 | ||
| Others (n = 229) | 35 (15.3) | 105 (45.9) | 51 (22.3) | 29 (12.7) | 9 (3.9) | 2.44 ± 0.07 | 1.967 | 0.160 | ||
a
CDI, Clostridium difficile infection.
b
CDI severity scores: 1, no clinical CDI; 2, mild CDI; 3, mild-to-moderate CDI; 4, moderate CDI; 5, moderate-to-severe CDI; 6, severe CDI (no cases observed).