TABLE 1.
Chemotherapy drugs, duration, and outcomes in the study patientsa
| Parameter | Mean ± SD |
Pb | |||
|---|---|---|---|---|---|
| Total (n = 34) | Culture conversion (n = 19) | Recurrence (n = 7) | Nonconversion (n = 8) | ||
| No. of drugs | 3.6 ± 0.6 | 3.5 ± 0.6 | 3.7 ± 0.5 | 3.4 ± 0.7 | 0.6165* |
| Drug combinations (no. of patients tested) | |||||
| RIF+EB+CAM | 13 | 6 | 3 | 4 | |
| RIF+EB+CAM+FQ | 6 | 5 | 0 | 1 | |
| RIF+EB+CAM+AMG | 8 | 5 | 2 | 1 | |
| RIF+CAM+FQ+AMG | 4 | 2 | 2 | 0 | |
| RIF+CAM+FQ | 3 | 1 | 0 | 2 | |
| Dose of clarithromycin (mg/day) | 535.3 ± 127.6 | 557.9 ± 126.1 | 542.9 ± 97.6 | 475 ± 148.8 | 0.4219* |
| Use of aminoglycoside (no. of subjects) | 12 | 7 | 4 | 1 | 0.1917‡ |
| Treatment period (yrs) | 1.8 ± 1.1 | 1.6 ± 0.2 | 2.3 ± 0.4 | 2.2 ± 0.4 | 0.1795* |
| Observation period (yrs) | 4.6 ± 1.2 | 4.5 ± 1.1 | 4.9 ± 0.9 | 4.3 ± 1.6 | 0.5358* |
| Time to culture conversion (yrs) | 0.4 ± 0.8 | 0.4 ± 0.2 | 0.3 ± 0.3 | NA | 0.7766† |
| Time to recurrence (yrs) | 2.0 ± 0.6 | NA | 2.0 ± 0.6 | NA | NA |
a
Data are presented as means ± the SD except as noted otherwise in column 1. NA, not applicable; RIF, rifampin; EB, ethambutol; CAM, clarithromycin; FQ, fluoroquinolones (levofloxacin [n = 7], moxifloxacin [n = 5], sitafloxacin [n = 1]); AMG, aminoglycoside (amikacin [n = 4], streptomycin [n = 8]).
b
P values were calculated using either the Kruskal-Wallis test (*) or the Mann-Whitney U test (†) for continuous values or the Fisher exact test (‡) for categorical variables.