TABLE 2.
Comparison of sensitivities, specificities, likelihood ratios, and predictive values determined by ID and the MVista anti-Coccidioides antibody EIA at different cutoff values and estimates of prevalence
| Test and cutoff value | Sensitivity (%) | Specificity (%) | LR+a | LR− | Prevalence of 5% |
Prevalence of 10% |
||
|---|---|---|---|---|---|---|---|---|
| PPV | NPV | PPV | NPV | |||||
| EIA, IgG | ||||||||
| 10 EU | 87.4 | 90.0 | 8.74 | 0.14 | 31.5 | 99.3 | 49.3 | 98.5 |
| 20 EU | 60.2 | 99.4 | 100.3 | 0.40 | 84.1 | 97.9 | 91.8 | 95.7 |
| EIA, IgM | ||||||||
| 10 EU | 61.2 | 95.3 | 13.0 | 0.41 | 40.7 | 97.9 | 59.1 | 95.7 |
| 20 EU | 30.1 | 99.4 | 50.2 | 0.70 | 72.5 | 96.4 | 84.8 | 92.8 |
| EIA, IgG or IgM | ||||||||
| 10 EU | 88.3 | 90.0 | 8.83 | 0.13 | 31.7 | 99.3 | 49.5 | 98.6 |
| 20 EU | 60.2 | 99.4 | 100.3 | 0.40 | 84.1 | 97.9 | 91.8 | 95.7 |
| IDCF | 53.3 | 98.8 | 44.5 | 0.47 | 70.0 | 97.6 | 83.1 | 95.0 |
| IDTP | 33.0 | 100 | ∞ | 0.67 | 100 | 96.6 | 100 | 93.1 |
| IDCF or IDTP | 60.1 | 98.8 | 50.1 | 0.40 | 72.5 | 97.9 | 84.8 | 95.7 |
a
LR+, positive likelihood ratio; LR−, negative likelihood ratio; PPV, positive predictive value; NPV, negative predictive value; IDCF, immunodiffusion with the CF antigen; IDTP, immunodiffusion with the TP antigen; ∞, perfect specificity results with an infinite positive likelihood ratio.