TABLE 3.
Analysis of parameters potentially affecting the sensitivity of anti-Coccidioides antibody detection
| Clinical factor and immunoglobulin | Sensitivity (%) |
P | |
|---|---|---|---|
| MVista EIA | IDa | ||
| Pulmonary disease (n = 72) | |||
| IgG | 90.2 | 45.8 | <0.0001 |
| IgM | 66.7 | 34.7 | <0.0001 |
| IgG or IgM | 90.2 | 54.2 | <0.0001 |
| Disseminated disease (n = 31) | |||
| IgG | 80.6 | 71.0 | 0.289 |
| IgM | 48.4 | 25.8 | 0.016 |
| IgG or IgM | 83.9 | 71.0 | 0.180 |
| Immunocompromised (n = 30) | |||
| IgG | 83.3 | 40.0 | 0.002 |
| IgM | 56.7 | 30.0 | 0.022 |
| IgG or IgM | 83.3 | 50.0 | 0.012 |
| Immunocompetent (n = 73) | |||
| IgG | 90.4 | 58.9 | <0.0001 |
| IgM | 63.0 | 32.9 | <0.0001 |
| IgG or IgM | 90.4 | 63.0 | <0.0001 |
| Antifungal treated (n = 78) | |||
| IgG | 87.2 | 57.7 | <0.0001 |
| IgM | 60.3 | 29.5 | <0.0001 |
| IgG or IgM | 88.5 | 62.3 | <0.0001 |
| Untreated (n = 25) | |||
| IgG | 88.0 | 40.0 | 0.005 |
| IgM | 64.0 | 40.0 | 0.109 |
| IgG or IgM | 88.0 | 52.0 | 0.004 |
a
IgG and IgM results refer to ID with the CF antigen and ID with the TP antigen, respectively.