(A) Sizes of calvarial lesions 7 days after P. gingivalis (Pg; 5 × 108 CFU) infection and the injection of miR-155 and anti-miR-2137. *, P < 0.05, n = 4. (B) Quantitative analysis of the index of ICI in each of the following groups: P. gingivalis-only infected, combination group (P. gingivalis and anti-miR-2137 plus miR-155), P. gingivalis and anti-miR-2137, and P. gingivalis and miR-155. *, P < 0.05. (C) Quantitative analysis of calvarial bone resorption in each of the following groups: P. gingivalis-only infected, combination group (P. gingivalis and anti-miR-2137 plus miR-155), P. gingivalis and anti-miR-2137, and P. gingivalis and miR-155. *, P < 0.05. (D) Quantitative analysis of osteoclast activity in each of the following groups: P. gingivalis-only infected, combination group (P. gingivalis and anti-miR-2137 plus miR-155), P. gingivalis and anti-miR-2137, and P. gingivalis and miR-155. *, P < 0.05.