TABLE 2.
Predicted pathways of the identified targets gene of selected miRNAsa
| Topological module and predicted pathways | Benjamini-corrected P value |
|---|---|
| 1 Olfactory transduction | 0.0E0 |
| 2 | |
| Neuroactive ligand-receptor interaction | 1.2E-107 |
| Taste transduction | 4.9E-36 |
| Calcium signaling pathway | 1.5E-19 |
| Chemokine signaling pathway | 2.7E-17 |
| Cytokine-cytokine receptor interaction | 4.3E-8 |
| Complement and coagulation cascades | 5.7E-6 |
| CyclicAMP signaling pathway | 6.6E-6 |
| 3 | |
| Ribosome | 1.2E-141 |
| Protein export | 1.3E-19 |
| 4 | |
| Cell cycle | 3.0E-86 |
| Progesterone-mediated oocyte maturation | 1.7E-25 |
| Oocyte meiosis | 1.7E-24 |
| HTLV-I infection | 1.8E-13 |
| p53 signaling pathway | 6.8E-12 |
| Viral carcinogenesis | 20.7E-11 |
| Ubiquitin-mediated proteolysis | 8.7E-11 |
| Small-cell lung cancer | 2.3E-9 |
| Hepatitis B | 1.2E-8 |
| FoxO signaling pathway | 3.5E-8 |
| Pathways in cancer | 2.3E-7 |
| 5 | |
| PPAR signaling pathway | 2.4E-21 |
| Thyroid hormone signaling pathway | 1.2E-19 |
| Adipocytokine signaling pathway | 3.6E-7 |
| Bile secretion | 4.3E-5 |
a
The predicted pathways of the five largest topological modules are presented. Only pathways with a Benjamini-corrected P value of <0.00001 were considered. Boldface type indicates pathways related to immune and inflammatory response.