FIG 2.

CpG treatment of chronically infected mice results in decreased lesion size and parasite burden. Following the development of lesions (∼4 weeks), BALB/c mice were injected perilesionally with 50 μg of CpG 1826, twice a week for 2 weeks for a total of four doses, indicated by arrows. Lesions were measured throughout the course of infection (A), and parasite burden was analyzed as described in Materials and Methods at the termination of the experiment (B). Data represent results from at least two independent experiments. ***, P ≤ 0.001.