FIG 10.

Cu deficiency promotes UPEC colonization in mice. (A) Tissue bacterial loads in control and Cu-deficient (Cu-Def) mice (CBA/J, 8 weeks old, n = 10/group) infected with UPEC strain CFT073 at 48 h postinoculation. Symbols represent bacterial burdens in a mouse, and bars represent median values. ***, P < 0.001; Mann-Whitney test. (B to E) Cu content of the livers (B), urine (C), bladders (D), and kidneys (E) of control and Cu-deficient mice was determined by ICP-MS. *, P < 0.05; **, P < 0.01; ***, P < 0.001; two-tailed t test. The mean and standard error of the mean are presented.