. Author manuscript; available in PMC: 2017 Jun 22.

Published in final edited form as: J Stat Theory Pract. 2016 Jun 22;10(3):574–587. doi: 10.1080/15598608.2016.1203843

Table 2.

Estimated causal quantities and 95% CIs from the delta method of diabetes/fasting plasma glucose on the relationship between BMI and CKD in the Jackson Heart Study based on the mediation formula approach.

	Binary Mediator Diabetes (yes or no)				Continuous Mediator Fasting Plasma Glucose (mg/dL)
	Risk Difference (%)		Odds Ratio		Risk Difference (%)		Odds Ratio

	Est.	95% CI	Est.	95% CI	Est.	95% CI	Est.	95% CI
Natural Indirect Effect IE(x)	0.78	0.47, 1.09	1.06	1.04, 1.08	0.45	0.28, 0.62	1.04	1.03, 1.06
Natural Direct Effect DE(x + 1)	2.31	1.21, 3.41	1.21	1.11, 1.32	2.52	1.42, 3.62	1.23	1.13, 1.34
Mediation Proportion (%) P(x)	25.3	12.7, 37.9	23.6	11.5, 35.6	15.1	7.5, 22.8	16.1	8.3, 23.9
Total Exposure Effect TE	3.09	1.99, 4.18	1.28	1.17, 1.39	2.97	1.87, 4.07	1.28	1.17, 1.39