TABLE 2.

Discrimination values of ribonucleotide analogs

Ribonucleotide analog	Danaloga (mean ± SD)
ATP analogs
3′-dATP	1.4 ± 0.5
2′-C-Me-ATP	3.7 ± 0.4
2′-C-ethynyl-7-deaza-ATP	5.7 ± 1.2
GTP analogs
3′-dGTP	3.7 ± 1.3
2′-C-Me-GTP	12.9 ± 0.1
2′-F-2′-C-Me-GTP	19.3 ± 4.0
CTP analogs
3′-dCTP	2.2 ± 0.5
2′-F-2′-C-Me-CTP	9.8 ± 1.1
2′-C-Me-CTP	6.7 ± 0.7
4′-C-azido-CTP	437.5 ± 79.9
UTP analogs
3′-dUTP	5.7 ± 1.2
2′-F-2′-C-Me-UTP	660.5 ± 64.3
2′-C-Me-UTP	53.2 ± 0.1
2′-C-ethynyl-UTP	4.9 ± 0.1

^aD_analog value = K_{1/2, analog}/K_{1/2, natural}. Data are from 2 or 3 independent experiments.