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PAE-SME results observed for time-kill curves for gepotidacin and comparator agents after 1 h of exposure at 5× MIC and addition of 0.25× MIC or 0.5× MIC of the antimicrobial agent
| N. gonorrhoeae isolate | Gepotidacin |
Ceftriaxone |
||||
|---|---|---|---|---|---|---|
| 5× MIC (μg/ml) | PAE-SME (h) at: |
5× MIC (μg/ml) | PAE-SME (h) at: |
|||
| 5× MIC + 0.25× MIC | 5× MIC + 0.5× MIC | 5× MIC + 0.25× MIC | 5× + 0.5× MIC | |||
| ATCC 49226 | 1.25 | >2.5 | >2.5 | 0.02 | 0.5 | 0.1 |
| 12584 | 0.625 | 1.2 | 2.7 | 0.02 | 1.3 | 0.0 |
