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(A) Total and unbound plasma concentration versus time of colistin after administration of single intratracheal (I.T.) doses of 2.64 and 5.28 mg base/kg and intravenous (I.V.) administration of 2.64 mg base/kg in neutropenic lung-infected mice. (B) ELF colistin concentration versus time after intratracheal administration of 2.64 and 5.28 mg base/kg colistin in neutropenic lung-infected mice.
