TABLE 1.
Pharmacokinetics parameters of colistin in ELF and plasmaa
| Parameter | Value after single dose |
||
|---|---|---|---|
| Intratracheal |
Intravenousc (2.64 mg base/kg) | ||
| 2.64 mg base/kg | 5.28 mg base/kg | ||
| ELF | |||
| Cmax,ELF (mg/liter) | 169b | 266b | ND |
| t1/2,ELF (min) | —d | 252 | ND |
| AUCELF (mg · h/liter) | 181 | 465 | ND |
| Plasma | |||
| Cmax (mg/liter) | 5.72 | 13.1 | ND |
| Tmax (min) | 30 | 30 | NA |
| CL/F (ml/min/kg) | 5.37 | 5.70 | 7.46 |
| V/F (ml/kg) | 181 | 284 | 400 |
| T1/2 (min) | 23.4 | 34.5 | 37.1 |
a
Shown are pharmacokinetics parameters of colistin in ELF and plasma following intratracheal administration of colistin at 2.64 and 5.28 mg/kg and intravenous administration of colistin at 2.64 mg base/kg (n = 3 or more).
b
Concentration observed at the first time point.
c
ND, not determined; NA, not applicable.
d
—, cannot be reliably estimated.