FIG 2.

Cumulative percent release of curcumin from nanoparticles under different conditions. (Top) Data for pH 1.8, 6.8, and 7.4, separately. The experiment was set up by assessing the release of the drug from nanoparticles in buffers at different pH levels over a period of 12 days. (Bottom) Data for pH 1.8 for the first 2 h and pH 6.8 for the next 4 h, followed by pH 7.4 for 24 h. A release study was performed by dialyzing CNP against pH 1.8 buffer for the initial 2 h to simulate gut conditions. Further, the release was carried out in a pH 6.8 sink buffer for the next 4 h and then pH 7.4 for 24 h of the experiment (intestinal environment).