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. 2017 Feb 23;61(3):e00498-16. doi: 10.1128/AAC.00498-16

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Copyright © 2017 Fofana et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Reuse of PZA increases the projected prevalence of pre-XDR TB. Projected prevalence of RIF-resistant (RIFr), FQ-resistant (FQr), and pre-XDR (RIF- and FQ-resistant [RIF/FQr] or RIF-, FQ-, and PZA-resistant [RIF/FQ/PZAr]) TB with and without additional resistance to PZA in 2035 under the baseline (A) and PZA replacement (B) scenarios. Box plots show the median, 25th, and 75th percentile values across all data-consistent simulations. Outlier simulations with a projected pre-XDR TB prevalence of greater than 20 per 100,000 population are not shown; the numbers of such outliers, if applicable, are indicated in parentheses at the top of each box plot. (C) Proportion of data-consistent simulations in which the projected pre-XDR TB prevalence in 2035 exceeds three predefined acceptability thresholds. Replacing PZA with an alternative drug of equal efficacy among patients with PZA-resistant TB greatly reduces the proportion of trajectories in which the prevalence exceeds the pre-XDR TB acceptability threshold in 2035.