TABLE 2.
Outcomes upon treatment completion, by resistance profile and treatment regimena
Final drug resistance profile | Probability (%) of: |
|||
---|---|---|---|---|
Cure |
Early relapse after cure |
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First-line agents | Second-line agents | First-line agents | Second-line agents | |
Drug susceptible | 89–99 | — | 4 | — |
RIFr | 40–64 | 89–94 | 16 | 4 |
FQr | 89–99 | — | 4 | — |
PZAr | 83–90 | — | 8 | — |
RIFr, FQr | 40–64 | 57–74 | 16 | 12 |
RIFr, PZAr | 32–59 | 76–86 | 16 | 8 |
FQr, PZAr | 83–90 | — | 8 | — |
RIFr, FQr, PZAr | 32–59 | 47–68 | 16 | 12 |
Additional details are provided in Table S1 in the supplemental material. —, not applicable, as the second-line regimen is assumed to be given only to patients with resistance to at least rifampin; RIFr, rifampin resistance; PZAr, pyrazinamide resistance; FQr, fluoroquinolone resistance.