TABLE 2.
Distribution of antifungal MICs and FKS mutations for 34 clinically resistant Candida glabrata isolates
| Antifungal compounda | No. of isolates (no. having FKS mutation) at MIC shown (μg/ml) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <0.01 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | |
| VT-1129 | —b | — | — | 3 (1) | 8c (6) | 10 (7) | 8 (7) | 5 (5) | — | — | — | — | — | — |
| VT-1161 | — | — | 1 | 5c (1) | 13 (12) | 5 (4) | 8 (7) | 2 (2) | — | — | — | — | — | — |
| FLC | — | — | — | — | — | 1 | 2 (1) | 6c (2) | 9 (8) | 4 (4) | 2 (1) | 4 (4) | 2 (1) | 4 (4) |
| VRC | 1 | — | 5 (2) | 12c (9) | 4 (4) | 3 (2) | 4 (4) | 3 (3) | 2 (2) | — | — | — | — | — |
| ANF | — | — | 3 (2) | 3 (2) | 7 (6) | 1 (1) | 3 | 7 (7) | 5 (4) | 5c (4) | — | — | — | — |
| MCF | 1 (1) | 2 (2) | 6 (5) | 4 (2) | 2 (2) | 7 (5) | 2 (2) | 1 | 5 (4) | 3c (2) | 1 (1) | — | — | — |
a
ANF, anidulafungin; FLC, fluconazole; MCF, micafungin; VRC, voriconazole.
b
—, no isolates tested had an MIC at this value.
c
One of the 34 strains was not tested for FKS mutations.