TABLE 4.

Spearman correlations of different factors predicting nephrotoxicity

Classification	P
	Total dose	Total duration	Dose (mg/kg)	Baseline serum creatininec
CTC > 50% binarya	0.226	0.313	0.159	0.000
CTC > 50% regressionb	0.200	0.321	0.220	0.001

^aThat is, a serum creatinine level above 50% of the baseline at any moment during treatment, as defined by the common toxicity criteria (22).

^bThat is, regression analysis on the different categories in toxicity, as defined by the common toxicity criteria (22).

^cBoth P values were significant at a 95% significance level.