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Biologically guided covariate screening plan
| Parameter | Covariates screened |
|---|---|
| Relative bioavailability (RELF) | Fed status,a dose, tablet strength, sex, age, race |
| Transit absorption rate (KTR) | Formulation, dose, tablet strength, sex, age, race |
| Central compartment vol (V) | Sex, age, race |
| Clearance (CL) | Dose, sex, age, race, smoker status |
| Peripheral compartment vol (VP1) | Sex, age, race |
Fed status effect on RELF was also assessed for a difference between formulations.
