FIG 1.

Bacteriological counts (log scale) in the bladders (a), implants (b), kidneys (c), and urine (d) of female LACA mice implanted with uncoated implants (△) or implants impregnated with a combination of azithromycin and ciprofloxacin (AZM-CIP) (▲) and infected with P. aeruginosa PAO1. Each symbol represents the value for an individual mouse from three independent experiments with five mice for each group. A horizontal bar denotes the mean value for the respective groups. Mice with AZM-CIP implants showed resistance to bacterial colonization and biofilm formation on implants (P ≤ 0.01) and in bladders (P < 0.0001), kidneys (P < 0.0001), and urine (P < 0.0001) in comparison to those of the uncoated implant group.