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. 2017 Feb 22;10:1017–1026. doi: 10.2147/OTT.S129343

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© 2017 Gao et al. This work is published and licensed by Dove Medical Press Limited

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Expression of linc-UBC1 in CRC and normal cells and its role in the regulation of proliferation.

Notes: (A) Expression of linc-UBC1 was markedly higher in the majority of CRC cell lines (SW620, HCT116, and HT29) compared with its expression in NCM460 colonic epithelial cells (*P<0.01). The SW620 cell line exhibited the highest expression level. No difference in expression was identified between SW480 and NCM460 cells. (B) Following treatment with si-linc-UBC1, linc-UBC1 expression in SW620 cell lines was significantly downregulated compared with that in si-NC-treated cells (*P<0.001). (C) The siRNA-mediated silencing of linc-UBC1 significantly inhibited cell proliferation in the SW620 cells (*P<0.05).

Abbreviations: linc-UBC1, long non-coding RNA upregulated in bladder cancer 1; CRC, colorectal carcinoma; siRNA, small interfering RNA; si-linc-UBC1, siRNA targeting linc-UBC1; si-NC, negative control siRNA; OD, optical density.