Table 1.

Correlation of DYRK2 expression and clinicopathological features in CRC

Features	Number of cases	DYRK2		P-value
		High	Low
Age at diagnosis (years)				0.920
≤50	57	26	31
>50	112	52	60
Gender				0.786
Female	108	49	59
Male	60	29	31
Location				0.814
Colon	82	39	43
Rectal	87	39	48
Clinical stage				0.026
I	21	14	7
II	26	16	10
III	50	21	29
IV	72	27	45
T classification				0.486
T1 + T2	32	13	19
T3 + T4	137	65	72
N classification				0.026
No	48	29	19
Yes	121	49	72
M classification				0.011
M0	92	50	42
M1	77	28	49
Pathologic differentiation				0.535
Poor	30	16	14
Moderate	125	57	68
Well	14	5	9

Notes: Correlation between DYRK2 expression and clinicopathological characteristics of CRC patients. Through the chi-square test we found DYRK2 was closely correlated with clinical stage (P=0.026), nodal (N) classification (P=0.026) and metastasis (M) classification (P=0.011) (determined by IHC staining).

Abbreviations: CRC, colorectal cancer; DYRK2, dual specificity tyrosine phosphorylation-regulated kinase 2; IHC, immunohistology.