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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Clin Toxicol. 2016 May 30;6(3):1000300. doi: 10.4172/2161-0495.1000300

Figure 1.

Figure 1

DZP induced hypotension is dose dependent and reversible by TPPU. Dose dependent effects of DZP on blood pressure are displayed for A. 1 mg/kg, B. 3 mg/kg and C. 10 mg/kg doses. Upon obtaining baseline BP (data before the break on the x-axis), mice were administered TPPU (i.p., 3 mg/kg) or vehicle (PEG400) 1 h before injection of DZP at varying dosages. Post-PEG400 or TPPU blood pressure was recorded for 2023 cycles (between 45–60 min). Then, DZP was administered and BP was recorded following 5 min after DZP injections. Timeline of the experiment is illustrated on panel A. Data are mean ± SEM. n=6 /group. D. Lipid epoxides such as EETs are endogenous chemical mediators known to return high blood pressure to normotensive levels. EETs are rapidly converted to DHETs by soluble epoxide hydrolase (sEH). This degradation is blocked by TPPU.