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DZP induced hypotension lasts for at least 6h. Time dependent effects of DZP at 3 mg/kg dose with or without TPPU on blood pressure (n=6 per group). Upon obtaining baseline BP, mice were administered TPPU (i.p., 3 mg/kg) 1 h before injection of DZP. Blood pressure was recorded at baseline, 45 min after TPPU or PEG400 administration, at 5 min after DZP (3 mg.kg) and then at 1, 2, 3, 4, 5 and 24 h. Data are mean ± SEM. n=6 /group.
