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Histological analysis of skin after treatment with different formulations.
Notes: The epidermal thickness was used to assess the epidermal hyperplasia. The mean of epidermal thickness was calculated based on 20 random site measurements. The concentration of FK506 in each formulation was 1 mg/mL. Scale bar: 100 μm.
Abbreviations: ANOVA, analysis of variance; CP, clobetasol propionate; FK506, tacrolimus; IMQ, imiquimod; NIC, nicotinamide; NPs, nanoparticles.
