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. 2017 Feb 22;12:1485–1497. doi: 10.2147/IJN.S126210

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© 2017 Wan et al. This work is published and licensed by Dove Medical Press Limited

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The epidermal thickness measured under the microscope.

Notes: The epidermal thickness was used to assess the epidermal hyperplasia. The mean of epidermal thickness was calculated based on 20 random site measurements. Significant differences were calculated using the ANOVA test (*P<0.05). The concentration of FK506 in each formulation was 1 mg/mL.

Abbreviations: ANOVA, analysis of variance; CP, clobetasol propionate; FK506, tacrolimus; IMQ, imiquimod; NIC, nicotinamide; NPs, nanoparticles.