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. Author manuscript; available in PMC: 2017 Feb 27.
Published in final edited form as: Development. 2007 Dec 12;135(2):367–375. doi: 10.1242/dev.013540

Fig. 6. A sequential recruitment and amplification model for Wnt-induced Lrp6 phosphorylation.

Fig. 6

(A) Initiation. Wnt-induced Fz-Lrp6 complex formation promotes initial Lrp6 phosphorylation via Dvl recruitment of the axin-Gsk3 complex. (B) Amplification. Initial Lrp6 phosphorylation provides docking sites and thereby recruits additional Axin-Gsk3 complex to promote further Lrp6 phosphorylation in cis and possibly in trans if/when Lrp6 multimerizes. See Discussion for details. For clarity, β-catenin, CK1 and other proteins are omitted from the axin complex, the protein composition of which may be different with and without Wnt stimulation.