Table 5. Risk of developing MetS by baseline albumin-corrected serum calcium tertile, stratified by the presence of two components of MetS.
| Variable | Corrected calcium tertile, mg/dL | P for trenda | Continuous variables HR (95% CI) | ||
|---|---|---|---|---|---|
| Tertile 1 (<8.70) |
Tertile 2 (8.70–8.94) |
Tertile 3 (>8.94) |
|||
| Subjects with two components of MetS (n=3,168) | 1,027 | 1,101 | 1,040 | ||
| No. of subjects incident cases, n (%) | 643 (62.6) | 630 (57.2) | 554 (53.3) | <0.001b | |
| Adjusted HR (95% CI)a | |||||
| Crude model | 1 (reference) | 0.89 (0.80–1.00) | 0.85 (0.76–0.95) | 0.016 | 0.76 (0.64–0.89) |
| Model 1 | 1 (reference) | 0.89 (0.80–1.00) | 0.86 (0.77–0.96) | 0.024 | 0.77 (0.65–0.90) |
| Model 2 | 1 (reference) | 0.87 (0.78–0.97) | 0.82 (0.73–0.92) | 0.002 | 0.71 (0.60–0.84) |
| Subjects with fewer than two components of MetS (n=9,538) | 3,236 | 3,227 | 3,075 | ||
| No. of subjects incident cases, n (%) | 566 (17.5) | 565 (17.5) | 490 (15.9) | 0.103b | |
| Adjusted HR (95% CI)a | |||||
| Crude model | 1 (reference) | 1.05 (0.93–1.18) | 1.03 (0.91–1.16) | 0.724 | 1.08 (0.90–1.29) |
| Model 1 | 1 (reference) | 1.05 (0.93–1.17) | 1.03 (0.91–1.17) | 0.751 | 1.10 (0.92–1.32) |
| Model 2 | 1 (reference) | 0.94 (0.83–1.05) | 0.89 (0.79–1.01) | 0.173 | 0.89 (0.74–1.08) |
Model 1: adjusted for age, sex; Model 2: adjusted for model 1+waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride, high density lipoprotein, fasting plasma glucose, smoking status, and conditions under medical treatment, including hypertension, diabetes, and hypercholesterolemia.
MetS, metabolic syndrome; HR, hazard ratio; CI, confidence interval.
aCox proportional hazard model (P<0.025 considered statistically significant after correction for multiple comparisons), bChi-square test for linear by linear association.