Fig. 1. Primary and secondary outcomes over 30 weeks for the per-protocol population: (A) change in glycosylated hemoglobin (HbA1c) values (primary outcome measure); (B) insulin glargine dose in the exenatide twice daily (BID) treatment group (open squares) and the insulin lispro treatment group (closed triangles), and total insulin dose in the insulin lispro group (closed circles); (C) change in fasting glucose; (D) self-monitored blood glucose values at randomization (gray lines) and 30 weeks (black lines); and (E) change in weight. Values are presented as mean±standard error. ^aP<0.05, ^bP≤0.01, ^cP<0.001.