Fig. 1.

Schematic of DMN subsystem elements. The within-DMN subsystems' connectivity for the ventral DMN (A), posterior DMN (B), anterior dorsal DMN (C), and anterior ventral DMN (D) are indicated with green capital letters near the medial surface rendering of their respective intrinsic connectivity networks used to create the DMN connectivity measures. The between-subsystems connectivity is indicated with red dashed lines (a–f). The ventral DMN hippocampal connectivity is indicated by the red dashed line extending from the ventral DMN to the medial temporal lobe (g). The surface renderings of the four independent components from the high-dimensional independent component analysis (ICA) Mayo Clinic Study of Aging Functional Connectivity Atlas [19] were created using the CARET software package http://www.nitrc.org/projects/caret/. The entire component maps were used in the dual-regression analysis. Elements A and B are used in the denominator in the NFQ and elements a and b are used in the numerator. This figure was originally published in the supplementary material of Jones et al. [1]. Abbreviation: DMN, default mode network.