Fig. 3.

Validating the biomarker potential of the optimized novel network failure quotient. Our summary measures of large-scale brain network failure (the optimized network failure quotient [oNFQ]) is plotted versus age and five biomarkers of Alzheimer's disease pathophysiology: (A) age, (B) tau-PET SUVR in the entorhinal cortex (EC), (C) amyloid-PET SUVR, (D) FDG-PET SUVR in Alzheimer's disease signature regions, (E) cortical thickness in Alzheimer's disease signature regions, (F) total score on the auditory verbal learning test. The blue line indicates the linear fit with the gray band indicating the 95% confidence interval. Inset in each plot, the correlation coefficient, P value, and the relative reduction in Akaike's information criteria (ΔAIC) between the models using oNFQ versus the ones using NFQ without optimization (see main text for details). Abbreviations: FDG, fluorodeoxyglucose; SUVR, standardized uptake value ratio.