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Quantification of changes to heart rate following S6c in TG control (A) and ETB‐def (B) rats expressed as area under the curve. a P < 0.05 versus 0.1 nmol/kg S6c; b P < 0.05 versus 0.3 nmol/kg S6c; TG Vehicle n = 4; TG Prazosin n = 5; TG Propranolol n = 4; ETB‐def Vehicle n = 5; ETB‐def Prazosin n = 5; ETB‐def Propranolol n = 4.; two‐way ANOVA. BW, body weight; S6c, sarafotoxin c; TG, transgenic; ETB‐def, endothelin type B‐deficient; ANOVA, analysis of variance.
