. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: J Pediatr. 2016 Dec 1;182:21–27.e2. doi: 10.1016/j.jpeds.2016.11.008

Table 2.

Effect of prophylactic indomethacin on vasopressor dependent hypotension

	Incidence of vasopressor use for at least 24 hours during days 4–7			Duration of vasopressor use ^**
	%			Hours Median (10^th −90^th percentile)
Vasopressor	Conservative Epoch (n=98)	Prophylactic epoch (n=215)	p-value	Conservative epoch	Prophylactic epoch	p-value
Dopamine -any	28	18	0.060	96 (35–96)	58 (27–96)	0.002
Dopamine ≥6 µg/kg/min	21	11	0.011	91 (42–96)	57 (33–96)	0.033
Dopamine ≥10 µg/kg/min	17	6	0.002	80 (37–96)	62 (28–96)	0.163
Hydrocortisone ^*	6	1	0.025	-	-	-

Incidence of hydrocortisone use when dopamine infusion rate ≥16 µg/kg/min

^**

Duration of vasopressor use among infants who received dopamine at the indicated infusion rate for at least 24 hours during postnatal days 4–7(maximum duration = 96 hours)