Table 4.
Effects of prophylactic indomethacin on vasopressor dependent hypotension at different levels of severity
| Model 1 | Model 2 | Model 3 | ||
|---|---|---|---|---|
|
Dopamine infusion rate |
Simple Model | Multivariate Model* without PDA variable in model |
Multivariate Model* including PDA variable in the model |
|
| Prophylactic Indomethacin |
Prophylactic Indomethacin |
Prophylactic Indomethacin |
Moderate/largeP DA on day 6–7 |
|
| Dopamine - any | ||||
| Odds Ratio | 0.58 | 0.54 | 1.20 | 3.52 |
| 95% CI | 0.33–1.02 | 0.29–1.01 | 0.51–2.82 | 1.52–8.14 |
| p-value | 0.060 | 0.056 | 0.676 | 0.003 |
|
Dopamine ≥6 µg/kg/min |
||||
| Odds Ratio | 0.41 | 0.40 | 0.89 | 3.38 |
| 95% CI | 0.23–0.79 | 0.20–0.82 | 0.34–2.30 | 1.32–8.60 |
| p-value | 0.007 | 0.011 | 0.806 | 0.011 |
|
Dopamine ≥10 µg/kg/min |
||||
| Odds Ratio | 0.31 | 0.30 | 0.70 | 3.58 |
| 95% CI | 0.14–0.66 | 0.13–0.70 | 0.22–2.26 | 1.10–11.67 |
| p-value | 0.003 | 0.005 | 0.549 | 0.034 |
*
Multivariate Model adjusted for delivery room intubation, surfactant, respiratory severity score at 24 hours after birth, gestational diabetes and male gender Prophylactic Indomethacin variable = prophylactic group versus conservative group; PDA variable = moderate/large PDA versus small or closed ductus present on postnatal day 6 or 7