Table 5.
Incidence of vasopressor dependent hypotension among infants with a moderate-to-large PDA during the Conservative and Prophylactic treatment epochs
| Incidence of vasopressor use for at least 24 hours during days 4–7 | ||||||
|---|---|---|---|---|---|---|
| Conservative epoch (n=98) | Prophylactic epoch (n=215) | |||||
| Vasopressor | PDA closed or small (n=35) |
PDA moderate-to- large (n=63) |
p-value | PDA closed or small (n=197) |
PDA moderate-to- large (n=18) |
p-value |
| % | % | % | % | |||
| Dopamine -any | 17 | 33 | 0.09 | 15 | 56 | <0.001 |
| Dopamine ≥6 µg/kg/min | 9 | 29 | 0.02 | 9 | 33 | 0.001 |
| Dopamine ≥10 µg/kg/min | 9 | 22 | 0.09 | 5 | 22 | 0.003 |
| Hydrocortisone * | 3 | 8 | 0.42 | 2 | 0 | 0.990 |
*
Incidence of hydrocortisone use when dopamine infusion rate ≥16 µg/kg/min