Table 1.
SOST RNA and sclerostin protein expression in bone and non-bone tissues.
| Cells/Tissue | Sample source | RNA/Protein |
|---|---|---|
| Musculoskeletal tissue | ||
| Bone | Whole long bone- human/mouse | RNA(2) |
| Mouse tibia, human hip bone, sclerosteosis patient mastoid | RNA(18) | |
| Osteocytes | Normal adult human bone | Protein(9) |
| E17.5 mouse mineralized bone, adult mouse tibia | RNA(18) | |
| Human bone | Protein(18) | |
| Osteoblasts | Primary human osteoblasts | RNA(9) |
| Human MSC derived osteoblasts | RNA(9) | |
| Human/mouse MSC derived mineralizing osteoblast cultures | RNA(18) | |
| Osteosarcoma | Human Saos2 cell line | RNA(43) |
| Human bone tumor biopsy | Protein(42) | |
| Osteoclasts | Mouse embryo | Protein(65) |
| Aged mouse bone marrow | RNA/Protein(66) | |
| Cartilage | Human/mouse | RNA(2) |
| Embryonic mouse (E15.5) ossifying cartilage | RNA(9) | |
| Hypertrophic chondrocytes | Human bone | Protein(9) |
| Human growth plate | Protein(19) | |
| Articular Cartilage-Osteoarthritis (OA) | Human OA cartilage | RNA/Protein(20) |
| Sheep, mouse surgery-induced OA cartilage | Protein(20) | |
| Human articular cartilage | RNA(21) | |
| Human cartilage | RNA/Protein(13) | |
| Human articular cartilage | RNA/Protein(22) | |
| STR/Ort OA mouse articular cartilage | RNA(30) | |
| Cementocytes | Human/mouse teeth | Protein(19) |
| IDG-CM6 mouse cementocyte cell line | RNA/Protein(11) | |
| Human/mouse teeth, mineralizing periodontal ligament cells | Protein(67) | |
| Multiple Myeloma | Patient CD138+ plasma cells and human cell lines H929, RPMI-8226, U266 and Karpas909 | RNA/Protein(48) |
| Soft tissue | ||
| Breast cancer | Human MDA-MB-231 cell line | RNA/Protein(50) |
| Prostate | Prostate nodular hyperplasia and prostate cancer | Protein(51) |
| Kidney | Human/mouse | RNA(2) |
| Liver | Human/mouse | RNA(2) |
| Human primary biliary cirrohsis biopsy | Protein(10) | |
| Heart | Mouse | RNA(2) |
| Aortic valves | Hemodialysis patient aortic valve | RNA/Protein |
| Brain | Mouse | RNA(2) |
| Thymus | Mouse | RNA(2) |
| Placenta | Human | RNA(2) |
| Fetal skin | Human | RNA(2) |