Table 1.
Demographic, Clinical and Echocardiographic Parameters by Quartile of Myocardial Contraction Fraction
| All | Quartile 1 (13.3 – 50.1%) |
Quartile 2 (50.1 – 57.8%) |
Quartile 3 (57.8 – 66.8%) |
Quartile 4 (66.8 – 106.8%) |
P value | |
|---|---|---|---|---|---|---|
| (N=2147) | (n=536) | (n=537) | (n=537) | (n=537) | ||
| Age (years) | 72.2±4.8 | 73.1±5.0 | 72.2±4.8 | 71.9±4.7 | 71.5±4.5±) | <0.001 |
| Men | 663 (31%) | 253 (47%) | 177 (33%) | 128 (24%) | 105 (20%) | <0.001 |
| Black | 286 (13%) | 99 (18%) | 68 (13%) | 67 (12%) | 52 (10%) | <0.001 |
| BMI (kg/m2) | 26.3 ±4.3 | 27.3±4.5 | 26.5±4.2 | 26.2±4.3 | 25.1±4.1 | <0.001 |
| Systolic BP (mm Hg) | 135±21 | 140±23 | 134±21 | 133±19 | 131±21 | <0.001 |
| Prevalent Diabetes | 230 (11%) | 86 (16%) | 60 (11%) | 46 (9%) | 38 (7%) | <0.001 |
| Alcohol use (drinks/week) | 2.5 (6.2%) | 3.1 (7.1%) | 2.5 (6.4%) | 2.2 (5.3%) | 2.4 (5.8%) | 0.03 |
| Smoker | 0.11 | |||||
| Never | 1051 (49.0%) | 235 (43.8%) | 272 (50.7%) | 273 (50.8%) | 271 (50.5%) | |
| Former | 839 (39.1%) | 227 (42.4%) | 209 (38.9%) | 194 (36.1%) | 209 (38.9%) | |
| Current | 257 (12.0%) | 74 (13.8%) | 56 (10.4%) | 70 (13.0%) | 57 (10.6%) | |
| Good/Excellent Health | 1829 (85.2%) | 446 (83.2%) | 463 (86.2%) | 456 (84.9%) | 464 (86.4%) | 0.43 |
| Income > $25,000 | 972 (45%) | 237 (44%) | 245 (46%) | 242 (45%) | 248 (46%) | 0.93 |
| Anti-hypertensive | 785 (37%) | 246 (46%) | 197 (37%) | 190 (35%) | 152 (28%) | <0.001 |
| Any lipid medication | 101 (5%) | 24 (4%) | 19 (4%) | 25 (5%) | 33 (6%) | 0.24 |
| LDLc (mg/dl) | 131±35 | 131± 33 | 134±37 | 130±36 | 130±34 | 0.22 |
| HDLc (mg/dl) | 57±16 | 54±15 | 56±16 | 59±15 | 61±16 | <0.001 |
| eGFR (ml/min/1.73 m2) | 82±19 | 77±19 | 83±18 | 83±17 | 84±19 | <0.001 |
| FEV1(liters) | 2.1±0.6 | 2.1±0.7 | 2.1±0.6 | 2.0±0.6 | 2.1±0.6 | 0.07 |
| Transmitral E/A ratio | <0.001 | |||||
| <0.7 | 301 (14%) | 107 (20%) | 82 (15.3%) | 65 (12.1%) | 47 (8.8%) | |
| 0.7 – 1.5 | 1772 (82.5%) | 413 (77.1%) | 440 (81.9%) | 458 (85.3%) | 461 (85.8%) | |
| >1.5 | 74 (3.5%) | 16 (2.9%) | 15 (2.8%) | 14 (2.6%) | 29 (5.4%) | |
| Fractional Shortening, %† | 43.0±7.5 | 39.3±8.0 | 42.5±7.1 | 43.9±6.6 | 46.1±6.7 | <0.001 |
| LA diameter (cm) | 3.8±0.6 | 3.9±0.6 | 3.8±0.6 | 3.8±0.6 | 3.7±0.6 | <0.001 |
| Percent predicted LV mass, | 109±30 | 128±30 | 112±20 | 104±20 | 92± 20 | <0.001 |
| Stroke volume (ml) | 77.0±19.0 | 70.9±19.1 | 76.4±18.8 | 78.8±17.3 | 82.2±18.9 | <0.001 |
| Myocardial volume (ml) | 136.0±42.0 | 168.8±50.6 | 141.4±34.7 | 127.1±28.0 | 108.7±26.0 | <0.001 |
| Valvular disease | 188 (8.8%) | 47 (8.8%) | 55 (10.2%) | 46 (8.6%) | 40 (7.4%) | 0.45 |
| Relative wall thickness | 0.35 (0.08) | 0.42 (0.09) | 0.36 (0.05) | 0.33 (0.05) | 0.29 (0.05) | <0.001 |
| NT-proBNP (pg/ml)† | 93.2 (49.3 – 176) | 107.4 (50.6 – 199.7) | 85.8 (40.8 – 175.1) | 88.19 (52.1 – 146.9) | 95.2 (53.8 – 168.8) | 0.004 |
*
Data were available in 2,143 subjects,
†
Data was available in 1,683 subjects and data is median (IQR).