Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Matrix Biol. 2016 Sep 7;57-58:86–105. doi: 10.1016/j.matbio.2016.08.008

Figure 1.

Figure 1

The role of laminins at the NMJ. Laminin chains have specific roles in organizing the presynaptic active zones and endplate morphology. (A) Represents an NMJ of adult wild-type mouse. (B) Represents an NMJ of laminin β2 knockout mouse. There is a loss of active zones, reduced number of synaptic vesicles and junctional folds, and infiltration of the synaptic cleft by Schwann cells. (C) Represents an NMJ of laminin α4 knockout mouse. There is a misalignment between active zones and junctional folds. (D) Represents an NMJ of laminin α4 and α5 double knockout mouse where the nerve terminal size is small. (E) Represents an NMJ laminin α2 knockout mouse where there is a reduced number of junctional folds and moderate infiltration of synaptic cleft by Schwann cells.