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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Neuroendocrinol. 2017 Feb;29(2):10.1111/jne.12455. doi: 10.1111/jne.12455

Figure 6. K-means cluster analysis of expression profiles across neuronal maturation Days 35–115.

Figure 6

Calinski and Silhouette index evaluation indicated 12 clusters as optimum to distinguish the 4079 genes that displayed significant differential expression (adjusted p-value<.01, absolute fold change>2) between at least two time points. The number of genes falling into each cluster are shown at the top of each plot. The y-axis plots the expression of each transcript centered and scaled so that each gene will have mean 0 and sd 1. The x axis plots days in culture. Cluster 1 showed statistically significant enrichment for BMI GWAS-implicated genes.