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. 2017 Feb 28;8:324. doi: 10.3389/fmicb.2017.00324

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Copyright © 2017 Liu, Zhang, Shi, Zhang, Li, Wang, Ling, Fu, Dong, Shen, Reeves, Greenberg, Zhao, Peng and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall structural differentiation of gut microbiota based on UniFrac distance between four groups. (A) OTU-level rarefaction (observed OTUs). (B) Chao 1 index. Values are shown by box-plot. Box represents the interquartile range. The line inside the box represents the median. And whiskers denote the minimum and maximum value. ^∗∗Adjusted P < 0.01 (Kruskal–Wallis test). (C) Bray–Curtis CAP using the first 13 PCs (accounting for 80.67% of the total variation). (D) Clustering of gut microbiota based on Bray–Curtis distance calculated with MANOVA using the first 13 PCs. ^∗∗P < 0.01. CN: non-obese control group, n = 9. CO: obese control group, n = 6. PN: non-obese PCOS group, n = 12. PO: obese PCOS group, n = 21.